Hello !
There is no interaction between NAC and SAMe with Lipitor. Both can also be taken together. However, I did a little research and was able to find that we do not have any data indicating NAC is effective for OCD. So I don't suggest you take it.
As for SAMe, there is some data on its use in depression. There's not a lot of evidence that it works, but it can be tried if you want a natural health product.
I would recommend that you see a doctor if you think you might be depressed or that you see a psychologist. Natural health products are generally not very effective and also have side effects
In the case of SAMe, the most reported side effects are: nausea, diarrhea, constipation, mild insomnia, dizziness, anxiety, irritability and sweating. Moreover, we have no data on its long-term use
I hope that I have answered your question correctly,
Louiza Lounas
Pharmacy intern (under the supervision of Alexandre Chagnon, Pharmacist).