Can I take it in the evening when I go to train or is it really not recommended? Thank you

Hello,

Before answering you, I would like to ask you some questions. Are you taking any other medications besides Synthroid and metformin? Do you have any other health conditions besides hypothyroidism and polycystic ovary syndrome? Do you have the doses of tyrosine, L-carnitine, agmatine and caffeine contained in this product and the dosage recommended by the manufacturer?

Tyrosine and L-carnitine could interact with Synthroid and hypothyroidism. Tyrosine is a precursor of thyroid hormones, so could theoretically increase the effect of Synthroid by increasing T4 and T3 levels and decreasing TSH. On the other hand, L-carnitine is a peripheral antagonist of thyroid hormones, so could decrease the effect of thyroid hormones and worsen the symptoms of hypothyroidism. Therefore, there is a possibility of unbalancing your hypothyroidism with this product. To evaluate the potential impact of these interactions, the doses of tyrosine and L-carnitine would have to be known. Also, the impact would be less if you take it occasionally as needed rather than regularly. If you decide to take it regularly and the doses are high, you will need to be consistent in your intake and schedule a blood test 4 weeks after starting the product and 4 weeks after stopping it to assess its impact on your TSH. If you experience symptoms of hypo- or hyperthyroidism, you should schedule a TSH test and consider discontinuing the product if an adjustment of the Synthroid dose cannot be considered.

Agmatine and caffeine could theoretically interact with metformin. Agmatine would have a mild hypoglycemic effect while caffeine could interfere with blood glucose levels in an unpredictable way, both up and down. Metformin could also theoretically decrease the metabolism of caffeine and increase its effect, but this effect has not been observed in humans. The impact of these interactions is minor and does not constitute an absolute contraindication. If you are taking this product, I would advise you to monitor your blood sugar levels more closely and to watch for symptoms of hypoglycemia by always carrying a source of glucose.

Sincerely,

Raphaël Parent, Pharmacist.

Since these are low doses and you plan to take them only occasionally rather than regularly every day, the risk of adverse effects is quite low. You can therefore take it without worry. However, if you notice any side effects, it is important to stop taking the product and consult your pharmacist.

The dose of caffeine is quite high for 1/2 scoop. For 1 scoop, that would be 324 mg of caffeine for a single dose, which is a lot in my opinion and could cause heart palpitations and insomnia, in addition to the potential interaction with metformin. So I would recommend no more than 1/2 scoop per dose.

Do not hesitate to contact me if you have any other questions.

Raphaël Parent, Pharmacist