If I take Vagi-fem (vaginal estrogen), should I also take progesterone to minimize the risk of uterine cancer?

Hello,

How often do you apply estrogen vaginally? Really every other day, regularly?

I find it a bit surprising that you are taking 3 separate products, when only one could potentially provide such effective relief from your vaginal discomfort and menopausal symptoms (hot flashes, among others). Let me explain.

Using Promensil, Gynatrof and Vagi-Fem only exposes you to small amounts of hormones. However, according to the recommendations consulted, there is a theoretical risk, which unfortunately cannot be quantified in this case, of developing uterine cancer. It is recommended to take a progestin then. This recommendation would be the same if you were taking hormones by mouth and Gynatrof by application instead. The latter option, however, exposes you to a slightly increased risk of side effects, considering the fact that the hormones are taken by mouth. It may, however, reduce the number of medications you need to take (if this is a problem for you) and potentially provide more adequate relief of your overall symptoms.

If taking progestin bothers you, you should know that there are now intrauterine devices that release a very small amount of progestin over a very long period of time (usually 3 to 5 years). Talk to your doctor if you are interested in this option.

We look forward to seeing you,

Alexandre

The evaluation of your particular situation at this level should be done with your doctor. In my opinion, the fact that you are pre-menopausal and taking very low doses of hormones induces a risk of endometrial cancer. This risk may be very low, but it is certainly not zero. Considering this fact, I think it would be interesting to consider the use of a low dose progestin, such as through a birth control pill or an IUD. In doing so, you will also have the contraceptive benefits associated with these products, if indicated.

Talk to your doctor!

And don't hesitate to write me again if you have any questions.