Hello, thank you for your question!
I have found a few studies showing that smoking can impair the body's repair functions, and also affect the effectiveness of Plaquenil
Smoking is a lifestyle habit that has known negative effects on the immune system and the body's ability to heal. Smoking cessation is strongly recommended
Fortunately, your pharmacist can prescribe smoking cessation aids to help you quit, if you so desire. I know that this is an addiction that is extremely difficult to address. Whether you decide to quit or not, I refer you to the Quit to Win Helpline: it's a professional and free service to support you in your efforts, whether you want to quit or need more information:
1 866 JARRETE (527-7383)
Monday to Thursday: 8 am to 9 pm
Friday: 8 am to 8 pm
As for alcohol, the information is not as clear: some mention a positive effect of occasional alcohol consumption while others find no association.
For your second question, it is true that an episode of illness, stress, fatigue or a change in schedule, among other things, can cause an imbalance in the hormonal cycle. If the situation persists, it is recommended to consult a physician.
I hope I've been helpful, and I'm available if you have any other questions!
Tom Samaha, pharmacist